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O negative blood is special because it is the universal blood type, meaning that it is the preferred choice for blood transfusions. This is especially true when the recipient’s blood type is unknown or in the case of an emergency when there is no time to test the recipient's blood group.
O negative blood is also the safest blood for transfusions in immune-deficient newborns, and it has the lowest risk of causing severe reactions for most recipients.
Because O negative blood is highly versatile, it is in high demand. However, people with O negative blood type can only receive blood from O negative donors.
What is the O negative blood group?
O negative blood group is a type of blood group that does not have any of the major blood group antigens (A, B, or Rh). Because of this, a person with any ABO and Rh blood type can receive O negative blood.
Blood type is determined based on the antigens present on the surface of the red blood cells. The two types of antigen categories that classify blood types are ABO antigens and Rh antigens.
Antigens are either protein or sugar molecules that have these prime functions in the blood:
- Maintaining the integrity of red blood cells
- Acting as receptors or binding sites for certain immune system components, enzymes, and other crucial molecules
- Transporting molecules in and out of the cell
Antigens and antibodies play a crucial role in the immune system’s defense mechanism. Antibodies are produced by white blood cells and target any antigen that is seen as a foreign object. It is therefore vital to receive a matching blood type during transfusion.
If a person receives blood with different antigens than those in their body, there is a high chance that their body will reject and attack the new blood cells.
Why is O negative blood group always in demand?
Since there is usually no time to test the blood type of a trauma victim, hospitals and ambulances need to have O negative blood to use in transfusions, as it is the safest option.
Although only 7% of people have O negative blood group in the United States, it is not the rarest. One of the rarest blood types is RH-null, which is present in 50 people in the entire world population.
Blood group ABO | Percentage of people |
---|---|
O-negative (O−) | 9% |
A-negative (A−) | 6% |
B-positive (B+) | 7% |
B-negative (B−) | 2% |
AB-positive (AB+) | 4% |
AB-negative (AB−) | 1% |
O-positive (O+) | 39% |
A-positive (A+) | 30% |

QUESTION
Sickle cell disease is named after a farming tool. See AnswerThe American National Red Cross. Why is Type O Blood so Important. https://www.redcrossblood.org/donate-blood/blood-types/o-blood-type.html
Cleveland Clinic. Blood Types. https://my.clevelandclinic.org/health/articles/21213-blood-types
Smith T. Is O Negative a Rare Blood Type? OneBlood. https://www.oneblood.org/media/blog/target-your-type/is-o-negative-a-rare-blood-type.stml
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